The human pre-B-specific lambda-like cluster is located in the 22q11.2-22q12.3 region, distal to the IgC lambda locus

Genomics. 1991 Mar;9(3):544-6. doi: 10.1016/0888-7543(91)90422-b.

Abstract

The chromosomal location of the lambda-like gene cluster, a gene family selectively expressed in human pre-B cells, was analyzed by in situ hybridization with a probe specific for the lambda-like genes. This cluster mapped in the q11.2-q12.3 region of chromosome 22. The use of Burkitt lymphoma and myelogenous leukemia cell lines with translocations in the 22q11 region led to a refinement in the location according to the following order: cen----BCRL2, VpreB, IgV lambda 1----BCRL4, IgV lambda----IgC lambda----BCR----BCRL3, lambda-like----tel. Unlike those of the mouse system, the pre-B-specific genes VpreB and lambda-like do not belong to the same transcriptional unit.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / cytology*
  • Burkitt Lymphoma
  • Chromosome Mapping
  • Chromosomes, Human, Pair 22*
  • Humans
  • Immunoglobulin lambda-Chains / genetics*
  • Leukemia, Myeloid
  • Mice
  • Multigene Family*
  • Nucleic Acid Hybridization
  • Translocation, Genetic / genetics
  • Tumor Cells, Cultured

Substances

  • Immunoglobulin lambda-Chains