Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A

Hirosato Takikawa; Naoki Kamatani; Kohei Nakanishi; Takuya Tashiro; Mitsuru Sasaki; Hiromi Yoshida; Yoshiyuki Mizushina

doi:10.1271/bbb.80629

Synthetic studies on kohamaic acids: synthesis of structurally simplified analogs of kohamaic acid A

Biosci Biotechnol Biochem. 2008 Nov;72(11):3071-4. doi: 10.1271/bbb.80629. Epub 2008 Nov 7.

Authors

Hirosato Takikawa¹, Naoki Kamatani, Kohei Nakanishi, Takuya Tashiro, Mitsuru Sasaki, Hiromi Yoshida, Yoshiyuki Mizushina

Affiliation

¹ Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Japan.

PMID: 18997393
DOI: 10.1271/bbb.80629

Abstract

Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships.

MeSH terms

Animals
Cattle
DNA Polymerase I / antagonists & inhibitors
DNA Polymerase beta / antagonists & inhibitors
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology
Rats
Structure-Activity Relationship
Terpenes / chemical synthesis*
Terpenes / chemistry*
Terpenes / pharmacology

Substances

Enzyme Inhibitors
Terpenes
kohamaic acid A
DNA Polymerase I
DNA Polymerase beta