Potential role of lipin-1 in exercise-induced mitochondrial biogenesis

Biochem Biophys Res Commun. 2008 Sep 26;374(3):587-91. doi: 10.1016/j.bbrc.2008.07.079. Epub 2008 Jul 24.

Abstract

Endurance exercise induces mitochondrial biogenesis in skeletal muscle. It has been shown that lipin-1 acts as a transcriptional coactivator in liver, and stimulates gene expression of mitochondrial enzymes. We hypothesized that lipin-1 might be involved in exercise-induced mitochondrial biogenesis in skeletal muscle. The present investigation first demonstrated that lipin-1 mRNA in rat triceps muscle was increased by approximately 2-fold after an acute bout of endurance swimming exercise. Second, ectopic expression of lipin-1 in L6 myotube increased carnitine palmitoyltransferase-1 and delta-aminolevulinate synthase gene expression. Finally, lipin-1 mRNA expression in rat triceps muscle was significantly elevated at 6h after subcutaneous injections of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) or clenbuterol, which are 5'-AMP-activated protein kinase (AMPK) and beta2-adrenergic receptor (beta2-AR) activators, respectively. These results may suggest that enhanced expression of lipin-1 is involved in exercise-induced mitochondrial enzyme adaptations, possibly through AMPK- and beta2-AR-related mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Aminolevulinate Synthetase / genetics
  • AMP-Activated Protein Kinase Kinases
  • Adrenergic beta-3 Receptor Agonists
  • Aminoimidazole Carboxamide / analogs & derivatives
  • Aminoimidazole Carboxamide / pharmacology
  • Animals
  • Carnitine O-Palmitoyltransferase / genetics
  • Clenbuterol / pharmacology
  • Epinephrine / blood
  • Gene Expression
  • Male
  • Mitochondria, Muscle / enzymology*
  • Muscle Fibers, Skeletal / metabolism
  • Muscle Fibers, Skeletal / ultrastructure
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / enzymology*
  • Muscle, Skeletal / ultrastructure
  • Norepinephrine / blood
  • Nuclear Proteins / genetics
  • Nuclear Proteins / physiology*
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Physical Conditioning, Animal
  • Physical Endurance* / genetics
  • Protein Kinases / metabolism
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / biosynthesis
  • Rats
  • Rats, Sprague-Dawley
  • Ribonucleotides / pharmacology
  • Swimming
  • Transcription Factors / biosynthesis

Substances

  • Adrenergic beta-3 Receptor Agonists
  • Lpin1 protein, rat
  • Nuclear Proteins
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
  • Ppargc1a protein, rat
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleotides
  • Transcription Factors
  • Aminoimidazole Carboxamide
  • Carnitine O-Palmitoyltransferase
  • 5-Aminolevulinate Synthetase
  • Protein Kinases
  • AMP-Activated Protein Kinase Kinases
  • AICA ribonucleotide
  • Norepinephrine
  • Clenbuterol
  • Epinephrine