[Anticoagulation and thrombophilia in pregnancy]

Internist (Berl). 2008 Jul;49(7):779-87. doi: 10.1007/s00108-008-2071-6.
[Article in German]

Abstract

A review of coagulation disturbances during pregnancy and the current management of the anticoagulated patient with heart valve prostheses, atrial fibrillation, and thromboembolic events is presented. All patients with mechanical heart valve prostheses require life-long oral anticoagulation with coumarin or one of its derivatives. Recommendations for the treatment and prevention of thromboembolic events are discussed. The advantages and disadvantages of three different treatment approaches to anticoagulation during pregnancy are discussed and recommendations for the management in different situations are outlined with delineation of specific risks for the mother and the fetus.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Anticoagulants / administration & dosage*
  • Female
  • Heart Valve Prosthesis / adverse effects*
  • Humans
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy*
  • Pregnancy Complications, Cardiovascular / prevention & control
  • Thrombophilia / drug therapy*
  • Thrombophilia / etiology*
  • Thrombophilia / prevention & control

Substances

  • Anticoagulants