A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line

K Witter; J Mautner; A Volgger; R Zahn; T Kauke

doi:10.1111/j.1399-0039.2007.01001.x

A novel HLA-DRB1 allele, HLA-DRB1*0465, was identified in a Hodgkin's lymphoma cell line

Tissue Antigens. 2008 Mar;71(3):257-8. doi: 10.1111/j.1399-0039.2007.01001.x. Epub 2008 Jan 8.

Authors

K Witter¹, J Mautner, A Volgger, R Zahn, T Kauke

Affiliation

¹ Laboratory of Immunogenetics, University Munich, Munich, Germany. klaus.witter@med.uni-muenchen.de

PMID: 18194364
DOI: 10.1111/j.1399-0039.2007.01001.x

Abstract

The new human leucocyte antigen-DRB1*0465 allele was identified in the Hodgkin's lymphoma cell line KM-H2. This novel allele differs from the DRB1*0406 allele by a single nucleotide exchange at position 288 (211) (A-->T), which results in an arginine to tryptophan amino acid replacement at codon 90 in the new allele.

MeSH terms

Alleles
Amino Acid Substitution
Base Sequence
Cell Line, Tumor
DNA Primers / genetics
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Histocompatibility Testing
Hodgkin Disease / genetics*
Hodgkin Disease / immunology*
Humans
Molecular Sequence Data
Polymorphism, Single Nucleotide
Terminology as Topic

Substances

DNA Primers
HLA-DR Antigens
HLA-DRB1 Chains

Associated data

GENBANK/AM765992