Molecular mechanisms of cerebral vasospasm following aneurysmal SAH

Neurol Res. 2007 Oct;29(7):636-42. doi: 10.1179/016164107X240224.

Abstract

Cerebral vasospasm following aneurysmal vasospasm has been the subject of intensive research. However the underlying pathophysiological mechanisms remain obscure. This article should summarize the present state concerning smooth muscle contraction, endothelial dysfunction, inflammatory changes, gene expression, in the genesis of vasospasm following aneurysmal subarachnoid hemorrhage.

Publication types

  • Review

MeSH terms

  • Animals
  • Cerebral Arteries / metabolism
  • Cerebral Arteries / physiopathology*
  • Endothelial Cells / metabolism
  • Gene Expression Regulation / physiology
  • Humans
  • Inflammation / metabolism
  • Inflammation / physiopathology
  • Inflammation Mediators / metabolism
  • Muscle, Smooth, Vascular / metabolism
  • Muscle, Smooth, Vascular / physiopathology*
  • Signal Transduction / physiology
  • Subarachnoid Hemorrhage / complications*
  • Vasospasm, Intracranial / etiology*
  • Vasospasm, Intracranial / metabolism
  • Vasospasm, Intracranial / physiopathology*

Substances

  • Inflammation Mediators