Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure

Fertil Steril. 2008 Oct;90(4):1246-8. doi: 10.1016/j.fertnstert.2007.09.008. Epub 2007 Dec 20.

Abstract

We studied the IZUMO gene 9 coding exons sequence in four groups of patients including those with fertilization failure by conventional IVF. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.

Publication types

  • Clinical Trial

MeSH terms

  • Cells, Cultured
  • Exons / genetics
  • Female
  • Fertilization / genetics*
  • Fertilization in Vitro
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Immunoglobulins / genetics*
  • Infertility, Male / genetics*
  • Infertility, Male / therapy
  • Male
  • Membrane Proteins / genetics*
  • Oocytes*
  • Pilot Projects
  • Polymorphism, Single Nucleotide / genetics
  • Pregnancy
  • Pregnancy Outcome*
  • Spermatozoa*

Substances

  • IZUMO1 protein, human
  • Immunoglobulins
  • Membrane Proteins