Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCMV

Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1553-8. doi: 10.1080/15257770701545424.

Abstract

Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.

MeSH terms

  • Adenosine / analogs & derivatives*
  • Adenosine / chemical synthesis
  • Adenosine / chemistry
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry*
  • Antiviral Agents / pharmacology*
  • Cytomegalovirus / drug effects*
  • HIV-1 / drug effects*
  • Humans
  • Ribonucleosides / chemical synthesis*
  • Ribonucleosides / chemistry
  • Uracil / analogs & derivatives*
  • Uracil / chemical synthesis
  • Uracil / chemistry
  • Uracil / pharmacology

Substances

  • 2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate
  • 2'-O-carbomoylmethyladenosine 3'-(thymidine 5'-phosphate)
  • 3-(3,5-dimethylbenzyl)uracil
  • Antiviral Agents
  • Ribonucleosides
  • Uracil
  • Adenosine