Abstract
Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is important for anti-HIV-1 activity, suggesting interaction with the amino acid residues of HIV-1 reverse transcriptase. 1-Arylmethyl derivatives also exhibited good anti-HIV-1 activity; and that of the 2- and 4-picolyl derivatives was particularly excellent.
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / chemistry
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry*
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Antiviral Agents / pharmacology*
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Cytomegalovirus / drug effects*
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HIV-1 / drug effects*
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Humans
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Ribonucleosides / chemical synthesis*
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Ribonucleosides / chemistry
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Uracil / analogs & derivatives*
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Uracil / chemical synthesis
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Uracil / chemistry
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Uracil / pharmacology
Substances
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2'-O-(carbomoylmethyl)ribonucleoside H-phosphonate
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2'-O-carbomoylmethyladenosine 3'-(thymidine 5'-phosphate)
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3-(3,5-dimethylbenzyl)uracil
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Antiviral Agents
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Ribonucleosides
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Uracil
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Adenosine