Abstract
A range of novel N-terminal lipid-functionalized peptide nucleic acid (PNA) monomers have been prepared and their abilities to inhibit HIV-1 reverse transcriptase and integrase have been examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-HIV Agents / chemical synthesis
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology*
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Drug Design
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HIV Integrase Inhibitors / chemical synthesis
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HIV Integrase Inhibitors / chemistry
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HIV Integrase Inhibitors / pharmacology
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HIV Reverse Transcriptase / antagonists & inhibitors
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HIV-1 / drug effects*
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Humans
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Microbial Sensitivity Tests
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Peptide Nucleic Acids / chemical synthesis
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Peptide Nucleic Acids / chemistry*
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Peptide Nucleic Acids / pharmacology*
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Reverse Transcriptase Inhibitors / chemical synthesis
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology
Substances
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Anti-HIV Agents
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HIV Integrase Inhibitors
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Peptide Nucleic Acids
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Reverse Transcriptase Inhibitors
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HIV Reverse Transcriptase