Inhibition of Escherichia coli DNA polymerase I catalysed DNA polymerization by trans-imidazolium-bisimidazoletetrachlororuthenate(III)

E Holler; W Schaller; B Keppler

Inhibition of Escherichia coli DNA polymerase I catalysed DNA polymerization by trans-imidazolium-bisimidazoletetrachlororuthenate(III)

Arzneimittelforschung. 1991 Oct;41(10):1065-8.

Authors

E Holler¹, W Schaller, B Keppler

Affiliation

¹ Institut für Biophysik und physikalische Biochemie, Universität Regensburg, Fed. Rep. of Germany.

PMID: 1799386

Abstract

The tumor-inhibiting metal complex trans-imidazolium-bisimidazoletetrachlororuthenate(III) (ICR) reacts with DNA and inhibits template-primer properties for DNA synthesis catalysed by Escherichia coli DNA polymerase I. The reaction with DNA depends on the aging (half-life 6.8 h) of the aqueous solution containing ICR. The kinetics of the reaction with DNA are reminiscent of those for cisplatin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA Polymerase I / antagonists & inhibitors*
DNA Replication / drug effects*
DNA, Bacterial / biosynthesis
DNA, Bacterial / drug effects
Escherichia coli / enzymology*
Imidazoles / chemistry
Imidazoles / pharmacology*
Kinetics
Organometallic Compounds*

Substances

DNA, Bacterial
Imidazoles
Organometallic Compounds
imidazolium-bis(imidazole)tetrachlororuthenate(III)
DNA Polymerase I