[ACE-inhibitor induced angioedema]

Laryngorhinootologie. 2007 Nov;86(11):804-8, quiz 809-13. doi: 10.1055/s-2007-966932.
[Article in German]

Abstract

ACE-inhibitor induced angioedema is a non-allergic drug-related side effect. Inhibited bradykinin degradation leads to an unphysiological enhanced bradykinin plasma level with vascular leakage and, consequently, to angioedema. ACE-inhibitor induced angioedema develop rapidly in the head and neck region. Typical sites of manifestation are lips, tongue, and larynx. Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Algorithms
  • Angioedema / blood
  • Angioedema / chemically induced*
  • Angioedema / diagnosis
  • Angioedema / diagnostic imaging
  • Angioedema / drug therapy
  • Angioedema / physiopathology
  • Angioedema / therapy
  • Angioedemas, Hereditary / diagnosis
  • Angiotensin-Converting Enzyme Inhibitors / adverse effects*
  • Angiotensin-Converting Enzyme Inhibitors / pharmacology
  • Bradykinin / analogs & derivatives
  • Bradykinin / blood
  • Bradykinin / physiology
  • Bradykinin / therapeutic use
  • Bradykinin Receptor Antagonists
  • Forecasting
  • Histamine Antagonists / therapeutic use
  • Humans
  • Laryngeal Edema / chemically induced*
  • Laryngeal Edema / diagnosis
  • Laryngoscopy
  • Magnetic Resonance Imaging
  • Time Factors
  • Tomography, X-Ray Computed

Substances

  • Adrenal Cortex Hormones
  • Angiotensin-Converting Enzyme Inhibitors
  • Bradykinin Receptor Antagonists
  • Histamine Antagonists
  • icatibant
  • Bradykinin