Platelet-derived growth factor, transforming growth factor-beta, and connective tissue growth factor in a porcine bronchial model of obliterative bronchiolitis

Exp Lung Res. 2007 Aug;33(6):303-20. doi: 10.1080/01902140701539745.

Abstract

The expression of platelet-derived growth factor (PDGF), transforming growth factor (TGF)-beta, and connective tissue growth factor (CTGF) and the effect of imatinib, an agent inhibiting PDGF receptors, were assessed in a porcine bronchial transplantation model of obliterative bronchiolitis (OB). Up-regulation of PDGF-A, PDGF receptors alpha and beta, and TGF-beta expression occurred in allografts, whereas PDGF-B and CTGF expression was similar in allo- and autografts. Imatinib modified the inflammatory responses and expression patterns of PDGF-A and PDGF receptors. This study further confirms PDGF and TGF-beta as mediators of OB and supports the concept of the importance of the pathways signaled through PDGF receptors in post-transplant OB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzamides
  • Bronchi / drug effects
  • Bronchi / metabolism*
  • Bronchi / pathology
  • Bronchi / transplantation
  • Bronchiolitis Obliterans / metabolism*
  • Bronchiolitis Obliterans / pathology
  • CD4-Positive T-Lymphocytes / pathology
  • CD8-Positive T-Lymphocytes / pathology
  • Connective Tissue Growth Factor
  • Disease Models, Animal
  • Graft Rejection / metabolism*
  • Graft Rejection / pathology
  • Imatinib Mesylate
  • Immediate-Early Proteins / metabolism*
  • Immunohistochemistry
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Macrophages / pathology
  • Piperazines / pharmacology
  • Platelet-Derived Growth Factor / metabolism*
  • Protein Kinase Inhibitors / pharmacology
  • Proto-Oncogene Proteins c-sis / metabolism*
  • Pyrimidines / pharmacology
  • Receptor, Platelet-Derived Growth Factor alpha / antagonists & inhibitors
  • Receptor, Platelet-Derived Growth Factor alpha / metabolism
  • Receptor, Platelet-Derived Growth Factor beta / antagonists & inhibitors
  • Receptor, Platelet-Derived Growth Factor beta / metabolism
  • Signal Transduction
  • Sus scrofa
  • Time Factors
  • Transforming Growth Factor beta / metabolism*
  • Transplantation, Autologous
  • Transplantation, Homologous

Substances

  • Benzamides
  • Immediate-Early Proteins
  • Intercellular Signaling Peptides and Proteins
  • Piperazines
  • Platelet-Derived Growth Factor
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins c-sis
  • Pyrimidines
  • Transforming Growth Factor beta
  • platelet-derived growth factor A
  • Connective Tissue Growth Factor
  • Imatinib Mesylate
  • Receptor, Platelet-Derived Growth Factor alpha
  • Receptor, Platelet-Derived Growth Factor beta