The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24

V Baud; M Lipinski; E Rassart; L Poliquin; D Bergeron

doi:10.1016/0888-7543(91)90124-w

The human homolog of the mouse common viral integration region, FLI1, maps to 11q23-q24

Genomics. 1991 Sep;11(1):223-4. doi: 10.1016/0888-7543(91)90124-w.

Authors

V Baud¹, M Lipinski, E Rassart, L Poliquin, D Bergeron

Affiliation

¹ Laboratoire de Biologie des Tumeurs, URA 1156 CNRS, Institut Gustave Roussy, Villejuif, France.

PMID: 1765382
DOI: 10.1016/0888-7543(91)90124-w

Abstract

FLI1 is a common mouse viral integration region in virus-induced leukemias and lymphomas. Using an evolutionarily conserved mouse probe and Southern hybridization to (rodent x human) somatic cell hybrid DNAs, the human homolog of FLI1 has been shown to lie on a fragment of chromosome 11 flanked on the centromeric side by the acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation breakpoint and on the telomeric side by the Ewing- and neuroepithelioma-associated t(11;22) (q24;q12) breakpoint.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blotting, Southern
Chromosome Mapping
Chromosomes, Human, Pair 11*
Humans
Mice
Virus Integration*