HLA-DQB1*0319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB1*1102

K Witter; J Mautner; T Albert; R Zahn; T Kauke

doi:10.1111/j.1399-0039.2007.00848.x

HLA-DQB10319, a novel HLA-DQB1 allele, shows strong haplotype association to HLA-DRB11102

Tissue Antigens. 2007 Jul;70(1):73-5. doi: 10.1111/j.1399-0039.2007.00848.x.

Authors

K Witter¹, J Mautner, T Albert, R Zahn, T Kauke

Affiliation

¹ Laboratory of Immunogenetics, University Munich, Max-Lebsche-Platz 32, 81377 Munich, Germany. klaus.witter@med.uni-muenchen.de

PMID: 17559588
DOI: 10.1111/j.1399-0039.2007.00848.x

Abstract

The new human leukocyte antigen-DQB1*0319 allele was identified in a prospective bone marrow donor by sequence-based typing. This novel allele differs from the DQB1*0301 allele at nucleotide position 554 (C-->T), which results in a Thr to Ile amino acid exchange. The new allele shows a strong association to DRB1*1102, suggesting that the haplotype DRB1*1102-DQB1*0319 is quite common.

MeSH terms

Alleles*
Base Sequence
DNA Primers
Exons
HLA-DQ Antigens / genetics*
HLA-DQ beta-Chains
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Haplotypes*
Heterozygote
Histocompatibility Testing
Humans
Introns
Isoleucine / metabolism
Linkage Disequilibrium
Living Donors
Membrane Glycoproteins / genetics*
Molecular Sequence Data
Nucleic Acid Amplification Techniques
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Substances

DNA Primers
HLA-DQ Antigens
HLA-DQ beta-Chains
HLA-DQB1 antigen
HLA-DR Antigens
HLA-DRB1 Chains
Membrane Glycoproteins
Isoleucine

Associated data

GENBANK/AM400970