Abstract
Signaling initiated by Class Ia phosphatidylinositol-3-kinases (PI3Ks) is essential for cell proliferation and survival. We discovered a novel protein we call PI3K interacting protein 1 (PIK3IP1) that shares homology with the p85 regulatory PI3K subunit. Using a variety of in vitro and cell based assays, we demonstrate that PIK3IP1 directly binds to the p110 catalytic subunit and down modulates PI3K activity. Our studies suggest that PIK3IP1 is a new type of PI3K regulator.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Catalytic Domain
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Cell Line
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Humans
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Intracellular Signaling Peptides and Proteins
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Kringles
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Membrane Proteins / physiology*
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Molecular Sequence Data
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Phosphatidylinositol 3-Kinases / metabolism*
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Protein Binding
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Protein Subunits
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Signal Transduction
Substances
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Intracellular Signaling Peptides and Proteins
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Membrane Proteins
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PIK3IP1 protein, human
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Protein Subunits