Abstract
Several anti-human immunodeficiency virus type 1 reverse transcriptase inhibitors were evaluated for their antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenine / analogs & derivatives
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Adenine / pharmacology
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Amino Acid Sequence
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Animals
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Antiviral Agents / pharmacology*
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Catalysis
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Cell Line
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Dose-Response Relationship, Drug
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Endogenous Retroviruses / drug effects*
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Endogenous Retroviruses / enzymology
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Endogenous Retroviruses / physiology
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HIV-1 / drug effects
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HIV-1 / enzymology
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Humans
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Kidney / cytology
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Molecular Sequence Data
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Organophosphonates / chemistry
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Organophosphonates / pharmacology*
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Polymerase Chain Reaction
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Protein Structure, Tertiary
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology*
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Stavudine / pharmacology
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Swine
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Swine, Miniature
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Tenofovir
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Virus Replication / drug effects*
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Zidovudine / pharmacology
Substances
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Antiviral Agents
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Organophosphonates
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Reverse Transcriptase Inhibitors
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Zidovudine
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adefovir
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Tenofovir
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Stavudine
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Adenine