Abstract
The purpose of these experiments was to test whether a brief course of insulin-like growth factor-1 (IGF-1) injection (escalating doses) concomitant to irradiation ameliorates radiation-induced kidney dysfunction and lethal bowel toxicity in a mouse model of unilateral high-dose irradiation of the kidney and adjacent bowel. The kidney function was assessed by means of repeated 99mTc-dimercaptosuccinate scans (every six weeks) during a maximum follow-up of 49 weeks. The experiments with single fractions of 12 Gy and 15 Gy revealed only minor differences in the severity of kidney dysfunction and no reduction in lethal bowel toxicity from IGF-1 treatment In the absence of any significant radioprotective effect, other strategies of response modification need to be developed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Dose-Response Relationship, Radiation
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Female
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Insulin-Like Growth Factor I / pharmacology*
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Intestinal Diseases / etiology
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Intestinal Diseases / prevention & control*
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Intestines / radiation effects
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Kidney / diagnostic imaging
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Kidney / radiation effects
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Kidney Diseases / diagnostic imaging
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Kidney Diseases / etiology
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Kidney Diseases / prevention & control*
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Mice
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Mice, Inbred C3H
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Radiation Injuries, Experimental / diagnostic imaging
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Radiation Injuries, Experimental / prevention & control*
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Radiation-Protective Agents / pharmacology*
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Radionuclide Imaging
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Radiopharmaceuticals
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Technetium Tc 99m Dimercaptosuccinic Acid
Substances
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Radiation-Protective Agents
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Radiopharmaceuticals
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Technetium Tc 99m Dimercaptosuccinic Acid
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Insulin-Like Growth Factor I