Activation of nuclear factor kappaB in acinar cells does not provoke acute pancreatitis

Gut. 2007 Feb;56(2):164-5. doi: 10.1136/gut.2006.105411.

Abstract

Acute pancreatitis does not result from nuclear factor κB activation in the pancreas but could inhibition of nuclear factor κB activation be of some benefit in the course of acute pancreatitis?

MeSH terms

  • Acute Disease
  • Animals
  • Cytokines / metabolism
  • Disease Models, Animal
  • Humans
  • I-kappa B Kinase / metabolism
  • NF-kappa B / antagonists & inhibitors
  • NF-kappa B / metabolism*
  • Pancreas / cytology*
  • Pancreas / metabolism
  • Pancreatitis / etiology*
  • Pancreatitis / metabolism
  • Trypsinogen / metabolism

Substances

  • Cytokines
  • NF-kappa B
  • Trypsinogen
  • I-kappa B Kinase