Discovery of non-nucleoside inhibitors of HIV-1 reverse transcriptase competing with the nucleotide substrate

Angew Chem Int Ed Engl. 2007;46(11):1810-3. doi: 10.1002/anie.200604165.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • HIV Reverse Transcriptase / genetics
  • Models, Molecular
  • Mutation
  • Nucleotides / metabolism*
  • Protein Conformation
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / pharmacology*
  • Reverse Transcriptase Inhibitors / chemical synthesis*
  • Reverse Transcriptase Inhibitors / metabolism
  • Reverse Transcriptase Inhibitors / pharmacology*

Substances

  • Nucleotides
  • Pyrimidines
  • Reverse Transcriptase Inhibitors
  • TNK-651
  • HIV Reverse Transcriptase