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In vitro treatment of human monocytes/macrophages with myristoylated recombinant Nef of human immunodeficiency virus type 1 leads to the activation of mitogen-activated protein kinases, IkappaB kinases, and interferon regulatory factor 3 and to the release of beta interferon.
J Virol. 2007 Mar;81(6):2777-91. doi: 10.1128/JVI.01640-06. Epub 2006 Dec 20.
J Virol. 2007.
PMID: 17182689
Free PMC article.
Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways.
He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE.
He JC, et al.
J Clin Invest. 2004 Sep;114(5):643-51. doi: 10.1172/JCI21004.
J Clin Invest. 2004.
PMID: 15343382
Free PMC article.
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