Lipoprotein-associated phospholipase A2 concentrations in plasma are associated with the extent of coronary artery disease and correlate to adipose tissue levels of marine n-3 fatty acids

Atherosclerosis. 2008 Jan;196(1):420-424. doi: 10.1016/j.atherosclerosis.2006.11.027. Epub 2006 Dec 8.

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor for cardiovascular disease. In the present study, plasma levels of Lp-PLA(2) were measured in patients (n=301) admitted to elective coronary angiography because of suspected coronary artery disease (CAD). In a multiple linear regression analysis, the degree of CAD (0-, 1-, 2- or 3-vessel disease) and plasma LDL cholesterol significantly correlated to Lp-PLA(2) levels. Also the content of the marine n-3 fatty acid, eicosapentaenoic acid (EPA) in adipose tissue, a measure of long-term intake of seafood independently and inversely (r=-0.18, p<0.01) correlated with plasma levels of Lp-PLA(2). The results support the view that Lp-PLA(2) may relate to CAD and that intake of marine n-3 fatty acids might reduce plasma Lp-PLA(2) suggesting another mechanism by which n-3 fatty acids could reduce the risk of cardiovascular disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / blood*
  • Adipose Tissue / chemistry*
  • Aged
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / physiopathology*
  • Denmark
  • Fatty Acids, Omega-3 / analysis*
  • Female
  • Humans
  • Linear Models
  • Male
  • Middle Aged
  • Risk Factors
  • Seafood

Substances

  • Fatty Acids, Omega-3
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase