2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Hiroshi Ohrui; Satoru Kohgo; Hiroyuki Hayakawa; Eiichi Kodama; Masao Matsuoka; Tomohiro Nakata; Hiroyuki Mitsuya

doi:10.1093/nass/nrl001

2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Nucleic Acids Symp Ser (Oxf). 2006:(50):1-2. doi: 10.1093/nass/nrl001.

Authors

Hiroshi Ohrui¹, Satoru Kohgo, Hiroyuki Hayakawa, Eiichi Kodama, Masao Matsuoka, Tomohiro Nakata, Hiroyuki Mitsuya

Affiliation

¹ Yokohama College of Pharmacy, Yokohama, Japan.

PMID: 17150787
DOI: 10.1093/nass/nrl001

Abstract

A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.

MeSH terms

Animals
Anti-HIV Agents / blood
Anti-HIV Agents / pharmacology*
Anti-HIV Agents / toxicity
Deoxyadenosines / blood
Deoxyadenosines / pharmacology*
Deoxyadenosines / toxicity
Drug Stability
HIV-1 / drug effects*
Mice
Reverse Transcriptase Inhibitors / blood
Reverse Transcriptase Inhibitors / pharmacology*
Reverse Transcriptase Inhibitors / toxicity

Substances

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine
Anti-HIV Agents
Deoxyadenosines
Reverse Transcriptase Inhibitors