Homology of placental protein 11 and pea seed albumin 2 with vitronectin

Biochem Biophys Res Commun. 1991 May 15;176(3):1000-6. doi: 10.1016/0006-291x(91)90381-g.

Abstract

Vitronectin (complement S-protein), a plasma and tissue glycoprotein of 75 kDa, shares the amino-terminal somatomedin B domain with the membrane glycoprotein PC1 of plasma cells and several hemopexin-type repeats with hemopexin and the non-catalytic carboxy-terminal domain of collagenases. It serves as a ligand for certain integrin receptors, binds to distinct members of the serpin family and inhibits the pore-forming cytolytic reaction of the terminal complement pathway. Computer-assisted data base searches revealed the presence of a single somatomedin B domain in the recently cloned placental protein 11, and four hemopexin-type repeats in the cytosolic plant protein PA2, the major albumin of pea seeds, whose function is unknown. Our finding shows that hemopexin-type repeats are present in extracellular as well as in cytosolic proteins and most likely originated before the divergence of the animal and plant kindoms.

Publication types

  • Comparative Study

MeSH terms

  • 2S Albumins, Plant
  • Albumins / genetics*
  • Amino Acid Sequence
  • Animals
  • Databases, Factual
  • Fabaceae / genetics*
  • Female
  • Glycoproteins / genetics*
  • Humans
  • Mice
  • Molecular Sequence Data
  • Plants, Medicinal*
  • Pregnancy
  • Pregnancy Proteins / genetics*
  • Sequence Homology, Nucleic Acid
  • Somatomedins / genetics
  • Vitronectin

Substances

  • 2S Albumins, Plant
  • Albumins
  • Glycoproteins
  • Pregnancy Proteins
  • Somatomedins
  • Vitronectin
  • pea seed albumin 2
  • placental protein 11
  • somatomedin B