Abstract
Transcriptional coactivators enhance gene expression by associating with sequence-specific transcription factors and serve as the primary targets of developmental and physiological signals in diverse biological processes. Recent studies have revealed key roles for transcriptional coactivators in the control of gene expression during development, growth and remodeling of the cardiovascular system. Based on the importance of the cardiovascular coactivators identified to date, coactivator control is emerging as a central regulatory mechanism in development and homeostasis of the cardiovascular system and other tissues.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Calmodulin-Binding Proteins / genetics
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Calmodulin-Binding Proteins / metabolism
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Cardiovascular System / cytology
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Cardiovascular System / embryology*
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Cardiovascular System / metabolism
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Gene Expression Regulation, Developmental / genetics*
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Humans
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Organogenesis / genetics*
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Protein Structure, Tertiary / physiology
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Trans-Activators / genetics*
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Trans-Activators / metabolism
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Transcription Factors / genetics*
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Transcriptional Activation / genetics*
Substances
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CAMTA2 protein, mouse
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Calmodulin-Binding Proteins
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Nuclear Proteins
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Trans-Activators
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Transcription Factors
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myocardin