Abstract
Hybridization studies using a panel of somatic cell hybrids with subchromosomal segments of 19q have localized the genes encoding hormone-sensitive lipase (LIPE), carcinoembryonic antigen (CEA), and small nuclear ribonucleoprotein polypeptide A (SNRPA) to various regions of 19q13.1; the cellular receptor for poliovirus sensitivity (PVS) to 19q13.2; and the genes coding for prostate-specific antigen (APS), human pancreatic kallikrein (KLK1), and small nuclear ribonucleoprotein 70-kD polypeptide (SNRP70) to 19q13.3----qter. Our results exclude several of these genes from being seriously considered as a candidate for the myotonic dystrophy gene on 19q.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antigens, Neoplasm / genetics
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Blotting, Southern
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Carcinoembryonic Antigen / genetics
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Chromosome Mapping*
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Chromosomes, Human, Pair 19*
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Genes
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Genetic Linkage
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Genetic Markers
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Humans
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Hybrid Cells
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Kallikreins / genetics
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Lipase / genetics
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Male
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Mice
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Myotonic Dystrophy / genetics*
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Poliovirus
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Prostate-Specific Antigen
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Prostatic Neoplasms / genetics
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Receptors, Virus / genetics
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Ribonucleoproteins / genetics
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Ribonucleoproteins, Small Nuclear
Substances
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Antigens, Neoplasm
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Carcinoembryonic Antigen
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Genetic Markers
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Receptors, Virus
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Ribonucleoproteins
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Ribonucleoproteins, Small Nuclear
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Lipase
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Kallikreins
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Prostate-Specific Antigen