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1: FEBS Lett. 1990 Oct 29;273(1-2):215-8.Links

A mitochondrial protein fraction catalyzing transport of the K+ analog T1+.

Diwan JJ, Paliwal R, Kaftan E, Bawa R.

Biology Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590.

A protein fraction has been obtained from detergent-solubilized mitochondrial membranes by its affinity for quinine, an inhibitor of K+ transport. A peptide derived from the predominant 53 kDa protein in this fraction is found to be identical in sequence to a portion of aldehyde dehydrogenase. Antigenically unrelated bands at 97, 77, 57, and 31 kDa are also seen on polyacrylamide gels. Observations utilizing a fluorescent probe entrapped in the lumen of membrane vesicles indicate that the reconstituted protein fraction imparts permeability to the K+ analog Tl+. These and other findings suggest that the affinity purified fraction includes a cation transport catalyst.

PMID: 1699808 [PubMed - indexed for MEDLINE]

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