Abstract
Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Bacterial Proteins / analysis*
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Carrier Proteins / analysis*
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DNA Polymerase II / analysis*
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Escherichia coli / enzymology
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HIV / enzymology*
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Hexosyltransferases*
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Humans
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Molecular Sequence Data
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Muramoylpentapeptide Carboxypeptidase / analysis*
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Penicillin-Binding Proteins
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Peptidyl Transferases*
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RNA-Directed DNA Polymerase / analysis*
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Sequence Homology, Nucleic Acid
Substances
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Bacterial Proteins
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Carrier Proteins
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Penicillin-Binding Proteins
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Peptidyl Transferases
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Hexosyltransferases
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RNA-Directed DNA Polymerase
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DNA Polymerase II
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Muramoylpentapeptide Carboxypeptidase