Inhibition of membrane potential-dependent amino acid transport by daptomycin

Antimicrob Agents Chemother. 1991 Dec;35(12):2639-42. doi: 10.1128/AAC.35.12.2639.

Abstract

Daptomycin inhibits the formation of UDP-N-acetylmuramyl-pentapeptide in Bacillus megaterium by inhibiting active transport of amino acids incorporated into the pentapeptide. The ability of daptomycin to inhibit active transport and peptidoglycan formation may be due to its ability to disrupt the transmembrane electrochemical gradient.

MeSH terms

  • Alanine / metabolism*
  • Anti-Bacterial Agents / pharmacology*
  • Bacillus megaterium / drug effects
  • Bacillus megaterium / metabolism
  • Biological Transport, Active / drug effects
  • Daptomycin
  • Diaminopimelic Acid / metabolism*
  • Glucose / metabolism
  • Glutamates / metabolism*
  • Glutamic Acid
  • Membrane Potentials / drug effects
  • Peptides / pharmacology

Substances

  • Anti-Bacterial Agents
  • Glutamates
  • Peptides
  • Glutamic Acid
  • Diaminopimelic Acid
  • Glucose
  • Daptomycin
  • Alanine