HIV-1 RNase H: recent progress in an exciting, yet little explored, drug target

Mini Rev Med Chem. 2006 Jun;6(6):727-37. doi: 10.2174/138955706777435733.

Abstract

HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / pharmacology
  • Binding Sites / drug effects
  • HIV-1 / enzymology*
  • HIV-1 / genetics
  • Nucleic Acid Synthesis Inhibitors / chemistry*
  • Nucleic Acid Synthesis Inhibitors / pharmacology
  • Protein Structure, Tertiary
  • Ribonuclease H / antagonists & inhibitors*
  • Ribonuclease H / chemistry
  • Ribonuclease H / metabolism

Substances

  • Anti-HIV Agents
  • Nucleic Acid Synthesis Inhibitors
  • Ribonuclease H