Abstract
HIV-1 reverse transcriptase-associated ribonuclease H (RNase H) is an attractive non traditional target for drug development which has been, so far, little explored. All drugs shown to inhibit HIV-1 RNase H are reported, including the recently described classes of compounds that interact with the metal ions in the active site.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Binding Sites / drug effects
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HIV-1 / enzymology*
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HIV-1 / genetics
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Nucleic Acid Synthesis Inhibitors / chemistry*
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Nucleic Acid Synthesis Inhibitors / pharmacology
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Protein Structure, Tertiary
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Ribonuclease H / antagonists & inhibitors*
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Ribonuclease H / chemistry
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Ribonuclease H / metabolism
Substances
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Anti-HIV Agents
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Nucleic Acid Synthesis Inhibitors
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Ribonuclease H