The Sp1 transcription factor gene (SP1) and the 1,25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome 7

Genomics. 1991 Sep;11(1):168-73. doi: 10.1016/0888-7543(91)90114-t.

Abstract

By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-gamma (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Southern
  • Calcitriol / metabolism*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 12*
  • Humans
  • Hybrid Cells
  • Rats
  • Receptors, Calcitriol
  • Receptors, Steroid / genetics*
  • Receptors, Steroid / metabolism
  • Sp1 Transcription Factor / genetics*

Substances

  • Receptors, Calcitriol
  • Receptors, Steroid
  • Sp1 Transcription Factor
  • Calcitriol