Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

Jeremy R Doncaster; Laura L Etchells; Neil M Kershaw; Ryoichi Nakamura; Hazel Ryan; Ryo Takeuchi; Kengo Sakaguchi; Ali Sardarian; Roger C Whitehead

doi:10.1016/j.bmcl.2006.03.005

Synthetic analogues of the manzamenones and plakoridines which inhibit DNA polymerase

Bioorg Med Chem Lett. 2006 Jun 1;16(11):2877-81. doi: 10.1016/j.bmcl.2006.03.005. Epub 2006 Mar 24.

Authors

Jeremy R Doncaster¹, Laura L Etchells, Neil M Kershaw, Ryoichi Nakamura, Hazel Ryan, Ryo Takeuchi, Kengo Sakaguchi, Ali Sardarian, Roger C Whitehead

Affiliation

¹ The School of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK.

PMID: 16563761
DOI: 10.1016/j.bmcl.2006.03.005

Abstract

An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases alpha and beta and human terminal deoxynucleotidyl transferase (TdT).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemical synthesis*
Biological Products / chemistry
Biological Products / pharmacology*
DNA Nucleotidylexotransferase / metabolism
DNA-Directed DNA Polymerase / metabolism
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
Molecular Structure
Nucleic Acid Synthesis Inhibitors*
Structure-Activity Relationship

Substances

Biological Products
Enzyme Inhibitors
Nucleic Acid Synthesis Inhibitors
DNA Nucleotidylexotransferase
DNA-Directed DNA Polymerase