Abstract
Enzymatic activity of DNA polymerase iota (Pol t) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol t activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol t oncogenic potential.
MeSH terms
-
Aged
-
Biomarkers, Tumor
-
DNA Polymerase iota
-
DNA-Directed DNA Polymerase / metabolism*
-
Deoxyadenine Nucleotides / chemistry
-
Deoxyguanine Nucleotides / chemistry
-
Electrophoresis, Polyacrylamide Gel
-
Eye / blood supply
-
Eye / enzymology
-
Female
-
Humans
-
Male
-
Melanoma / enzymology*
-
Middle Aged
-
Uveal Neoplasms / enzymology*
Substances
-
Biomarkers, Tumor
-
Deoxyadenine Nucleotides
-
Deoxyguanine Nucleotides
-
deoxyguanosine triphosphate
-
DNA-Directed DNA Polymerase
-
2'-deoxyadenosine triphosphate
-
DNA Polymerase iota
-
POLI protein, human