Making digit patterns in the vertebrate limb

Nat Rev Mol Cell Biol. 2006 Jan;7(1):45-53. doi: 10.1038/nrm1830.

Abstract

The vertebrate limb has been a premier model for studying pattern formation - a striking digit pattern is formed in human hands, with a thumb forming at one edge and a little finger at the other. Classic embryological studies in different model organisms combined with new sophisticated techniques that integrate gene-expression patterns and cell behaviour have begun to shed light on the mechanisms that control digit patterning, and stimulate re-evaluation of the current models.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Body Patterning*
  • Embryonic Development* / genetics
  • Extremities / embryology*
  • Humans