Immunogenicity of sequential pneumococcal vaccination in subjects splenectomised for hereditary spherocytosis

Br J Haematol. 2006 Mar;132(6):788-90. doi: 10.1111/j.1365-2141.2005.05918.x.

Abstract

Splenectomy predisposes for invasive pneumococcal disease. We investigated the immune response of splenectomised hereditary spherocytosis (HS) patients upon sequential pneumococcal vaccination. Thirty-nine HS-patients (2- to 18-year-old) had undergone near-total or total splenectomy. All received one dose of 7-valent pneumococcal conjugate vaccine (PCV-7) and 23-valent-pneumococcal-polysaccharide vaccine (PPV-23) 2 months apart. Pneumococcal antibodies against serotypes 5/6B/7/14/18C/19F/23F and immunoglobulin serum concentrations were determined before PCV-7 and 4 weeks after PPV-23. Significant rises in antibody geometric mean concentrations were observed after PCV-7 except for serotypes 5 and 7, which increased after PPV-23. We found no impact of the mode of splenectomy.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Adolescent
  • Antibodies, Bacterial / analysis
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Male
  • Pneumococcal Infections / immunology
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / blood
  • Pneumococcal Vaccines / immunology*
  • Prospective Studies
  • Serotyping / methods
  • Spherocytosis, Hereditary / blood
  • Spherocytosis, Hereditary / immunology*
  • Spherocytosis, Hereditary / surgery
  • Splenectomy / adverse effects*
  • Splenectomy / methods
  • Vaccines, Conjugate / immunology

Substances

  • Antibodies, Bacterial
  • Immunoglobulin A
  • Immunoglobulin G
  • Pneumococcal Vaccines
  • Vaccines, Conjugate