Abstract
ELMO is an upstream regulator of the Rho family small GTPase Rac. We investigated the distributions of mRNAs of two subtypes of ELMO, ELMO1 and ELMO2, in the developing mouse brain. Both ELMO1 and ELMO2 mRNAs are widely distributed in the developing mouse brain, but they were expressed in different neuronal populations in the cerebral cortex, thalamus, and cerebellum. Thus, ELMO1 and ELMO2 may play different roles during brain development.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Animals, Newborn
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Brain / enzymology
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Brain / growth & development
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Brain / metabolism*
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Cytoskeletal Proteins / genetics
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Cytoskeletal Proteins / metabolism*
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Embryo, Mammalian
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Gene Expression / physiology
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In Situ Hybridization / methods
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Mice
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RNA, Messenger / metabolism*
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Reverse Transcriptase Polymerase Chain Reaction / methods
Substances
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Adaptor Proteins, Signal Transducing
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Cytoskeletal Proteins
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ELMO1 protein, mouse
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RNA, Messenger