Abstract
Raver2 was identified as a novel member of the hnRNP family based on sequence homology within three RNA recognition motifs and its general domain organization reminiscent of the previously described raver1 protein. Like raver1, raver2 contains two putative nuclear localization signals and a potential nuclear export sequence, and also displays nucleo-cytoplasmic shuttling in a heterokaryon assay. In glia cells and neurons, raver2 localizes to the nucleus. Moreover, the protein interacts with polypyrimidine tract binding protein (PTB) suggesting that it may participate in PTB-mediated nuclear functions. In contrast to ubiquitously expressed raver1, raver2 exerts a distinct spatio-temporal expression pattern during embryogenesis and is essentially restricted to brain, lung, and kidney in the adult mouse.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Carrier Proteins / metabolism
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Cell Nucleus / chemistry
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Cell Nucleus / metabolism
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Cytoplasm / chemistry
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Cytoplasm / metabolism
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Embryo, Mammalian / metabolism
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Embryonic Development
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Heterogeneous-Nuclear Ribonucleoproteins / chemistry*
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Heterogeneous-Nuclear Ribonucleoproteins / classification
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Heterogeneous-Nuclear Ribonucleoproteins / metabolism*
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Humans
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Mice
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Molecular Sequence Data
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Neuroglia / cytology
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Neurons / chemistry
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Neurons / metabolism
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Nuclear Localization Signals
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Nuclear Proteins / metabolism
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Polypyrimidine Tract-Binding Protein / analysis
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Polypyrimidine Tract-Binding Protein / metabolism
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Protein Transport
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RNA-Binding Proteins
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Ribonucleoproteins
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Tissue Distribution
Substances
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Carrier Proteins
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Heterogeneous-Nuclear Ribonucleoproteins
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Nuclear Localization Signals
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Nuclear Proteins
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RNA-Binding Proteins
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Raver1 protein, mouse
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Raver2 protein, mouse
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Ribonucleoproteins
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Polypyrimidine Tract-Binding Protein