Abstract
Five new acylphloroglucinol derivatives, mahureones A-E (1, 3-6), have been isolated from the leaves of Mahurea palustris, and their structures determined by spectroscopic means. During the isolation process, several byproducts (7-9) were formed by reaction of one of the isoprenyl side chains with TFA, water, and acetonitrile. All the compounds were assayed for their ability to inhibit human DNA polymerase beta. The most active compounds, mahureones A (1) and D (5), exhibited IC50 values in the 10 microM range.
MeSH terms
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Clusiaceae / chemistry*
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DNA Polymerase beta / antagonists & inhibitors*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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French Guiana
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Phloroglucinol* / analogs & derivatives
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Phloroglucinol* / chemistry
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Phloroglucinol* / isolation & purification
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Phloroglucinol* / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal / chemistry*
Substances
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Enzyme Inhibitors
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Phloroglucinol
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DNA Polymerase beta