Association study between the D10S1423 microsatellite marker and Alzheimer's disease

Neurobiol Aging. 2006 May;27(5):776.e1-776.e3. doi: 10.1016/j.neurobiolaging.2005.02.016. Epub 2005 Jul 18.

Abstract

Several studies have reported conflicting results concerning the genetic association between Alzheimer's disease (AD) and the microsatellite marker D10S1423 on chromosome 10p12-14. In an ethnically homogeneous German population of 422 patients with AD and 254 cognitively healthy controls, the 238-bp allele of the D10S1423 marker showed a weak, but after correction for multiple testing no longer significant association with AD (p = 0.015, uncorrected; p = 0.11, corrected). These findings do not support the presence of a relevant susceptibility locus for AD on chromosome 10p12-14.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alleles
  • Alzheimer Disease / epidemiology
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics
  • Chromosomes, Human, Pair 10 / genetics
  • Cohort Studies
  • Female
  • Gene Frequency
  • Germany / epidemiology
  • Humans
  • Male
  • Microsatellite Repeats*

Substances

  • Apolipoprotein E4
  • Apolipoproteins E