Association study of polymorphisms within matrix metalloproteinase 9 with bronchial asthma

Int J Immunogenet. 2005 Aug;32(4):233-6. doi: 10.1111/j.1744-313X.2005.00516.x.

Abstract

Matrix metalloproteinase 9 plays an important role in the development of bronchial asthma. We were interested in whether the polymorphisms -T1702A, -C1562T, R279Q and +C6T within the matrix metalloproteinase 9 (MMP-9) gene were associated with asthma in a population of 231 asthmatic children. However, we found no association. Thus MMP-9 might not be a major gene for asthma.

MeSH terms

  • Adolescent
  • Asthma / enzymology
  • Asthma / genetics*
  • Asthma / physiopathology
  • Case-Control Studies
  • Child
  • Haplotypes / genetics
  • Humans
  • Matrix Metalloproteinase 9 / genetics*
  • Polymorphism, Genetic / genetics*

Substances

  • Matrix Metalloproteinase 9