Enhanced fidelity in mismatch extension by DNA polymerase through directed combinatorial enzyme design

Angew Chem Int Ed Engl. 2005 Jul 25;44(30):4712-5. doi: 10.1002/anie.200500047.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Pair Mismatch*
  • DNA Polymerase I / genetics*
  • Escherichia coli / enzymology
  • Gene Library
  • Genetic Testing
  • Genetic Variation
  • Models, Molecular
  • Mutation
  • Peptide Library
  • Polymerase Chain Reaction / methods
  • Protein Conformation
  • Sensitivity and Specificity

Substances

  • Peptide Library
  • DNA Polymerase I