Alzheimer pathology associated with POLG1 mutation, multiple mtDNA deletions, and APOE4/4: premature ageing or just coincidence?

Acta Neuropathol. 2005 Sep;110(3):315-6. doi: 10.1007/s00401-005-1047-z. Epub 2005 Jun 25.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age of Onset
  • Aging / genetics
  • Aging, Premature / genetics*
  • Aging, Premature / metabolism
  • Aging, Premature / physiopathology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / physiopathology
  • Apolipoprotein E4 / genetics*
  • DNA Mutational Analysis
  • DNA Polymerase gamma
  • DNA, Mitochondrial / genetics*
  • DNA-Directed DNA Polymerase / genetics*
  • Disease Progression
  • Female
  • Gene Deletion
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics
  • Genetic Testing
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Mitochondrial Myopathies / genetics
  • Mitochondrial Myopathies / metabolism
  • Mitochondrial Myopathies / physiopathology
  • Mutation / genetics
  • Ophthalmoplegia, Chronic Progressive External / genetics*
  • Ophthalmoplegia, Chronic Progressive External / metabolism
  • Ophthalmoplegia, Chronic Progressive External / physiopathology
  • Siblings
  • Sweden

Substances

  • Apolipoprotein E4
  • DNA, Mitochondrial
  • Genetic Markers
  • DNA Polymerase gamma
  • DNA-Directed DNA Polymerase
  • POLG protein, human