Abstract
The saline leaf extract of Bryophyllum pinnatum was investigated on neuropharmacological activities to ascertain claims of local use. When tested in mice, it produced a dose-dependent prolongation of onset and duration of pentobarbitone-induced hypnosis, reduction of exploratory activities in the head-dip and evasion tests. Moreover, a dose-dependent muscle in-coordination was observed in the inclined screen, traction and climbing tests. It delayed onset to convulsion in both strychnine- and picrotoxin-induced seizures in addition to minimal protection against picrotoxin seizures.
MeSH terms
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Administration, Oral
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Animals
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Anticonvulsants / administration & dosage
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Anticonvulsants / pharmacology*
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Anticonvulsants / therapeutic use
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Behavior, Animal / drug effects
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Crassulaceae*
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Dose-Response Relationship, Drug
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Exploratory Behavior / drug effects
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Female
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Male
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Mice
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Neuromuscular Blocking Agents / administration & dosage
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Neuromuscular Blocking Agents / pharmacology*
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Neuromuscular Blocking Agents / therapeutic use
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Phytotherapy*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Leaves
Substances
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Anticonvulsants
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Neuromuscular Blocking Agents
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Plant Extracts