DNA polymerase clamp loaders and DNA recognition

Gregory D Bowman; Eric R Goedken; Steven L Kazmirski; Mike O'Donnell; John Kuriyan

doi:10.1016/j.febslet.2004.11.038

DNA polymerase clamp loaders and DNA recognition

FEBS Lett. 2005 Feb 7;579(4):863-7. doi: 10.1016/j.febslet.2004.11.038.

Authors

Gregory D Bowman¹, Eric R Goedken, Steven L Kazmirski, Mike O'Donnell, John Kuriyan

Affiliation

¹ Departments of Molecular and Cell Biology and Chemistry, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

PMID: 15680964
DOI: 10.1016/j.febslet.2004.11.038

Abstract

Clamp loaders are heteropentameric ATPase assemblies that load sliding clamps onto DNA and are critical for processive DNA replication. The DNA targets for clamp loading are double-stranded/single-stranded junctions with recessed 3' ends (primer-template junctions). Here, we briefly review the crystal structures of clamp loader complexes and the insights they have provided into the mechanism of the clamp loading process.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Adenosine Triphosphatases / chemistry*
Adenosine Triphosphatases / metabolism*
Adenosine Triphosphate / metabolism
DNA / metabolism
DNA Polymerase III / metabolism
DNA Replication / physiology*
DNA-Binding Proteins / chemistry*
DNA-Binding Proteins / metabolism*
DNA-Directed DNA Polymerase / metabolism*
Models, Molecular
Protein Conformation

Substances

DNA-Binding Proteins
Adenosine Triphosphate
DNA
beta subunit, DNA polymerase III
DNA Polymerase III
DNA-Directed DNA Polymerase
Adenosine Triphosphatases

Abstract

Publication types

MeSH terms

Substances

Grants and funding