Abstract
TLR2(-/-)/scid double-mutant mice were infected with B. burgdorferi to assess the relative importance of acquired and innate host defenses. Although spirochete levels at 4 weeks were lower in TLR2(-/-) mice than in TLR2(-/-)/scid mice, the increased arthritis severity of TLR2 (Toll-like receptor 2)-deficient mice was reduced by the presence of the scid mutation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Borrelia burgdorferi / isolation & purification*
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Immunity, Innate
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Joints / pathology
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Lyme Disease / immunology*
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Lyme Disease / microbiology
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Lyme Disease / pathology
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Mice
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Mice, Inbred C3H
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Mice, Inbred C57BL
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Mice, SCID
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Receptors, Cell Surface / physiology*
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Toll-Like Receptor 2
Substances
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Receptors, Cell Surface
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Tlr2 protein, mouse
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Toll-Like Receptor 2