How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

Paula L Fischhaber; Errol C Friedberg

doi:10.1016/j.dnarep.2004.08.011

How are specialized (low-fidelity) eukaryotic polymerases selected and switched with high-fidelity polymerases during translesion DNA synthesis?

DNA Repair (Amst). 2005 Feb 3;4(2):279-83. doi: 10.1016/j.dnarep.2004.08.011.

Authors

Paula L Fischhaber¹, Errol C Friedberg

Affiliation

¹ Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9072, USA. paula.fischhaber@utsouthwestern.edu

PMID: 15590336
DOI: 10.1016/j.dnarep.2004.08.011

Abstract

Specialized DNA polymerases are required in both prokaryotic and eukaryotic cells for bypassing sites of template DNA damage that arrest high-fidelity DNA replication. Recent studies in the literature provide hints of the complexity of DNA switching between polymerases for translesion DNA synthesis (TLS) and those for normal DNA replication.

Publication types

Review

MeSH terms

Animals
DNA Damage*
DNA Repair / physiology*
DNA Replication / physiology*
DNA-Directed DNA Polymerase / physiology*
Eukaryotic Cells / physiology
Humans
SUMO-1 Protein / physiology
Ubiquitin / physiology

Substances

SUMO-1 Protein
Ubiquitin
DNA-Directed DNA Polymerase