Marine sesquiterpenoids that inhibit the lyase activity of DNA polymerase beta

J Nat Prod. 2004 Oct;67(10):1716-8. doi: 10.1021/np049849+.

Abstract

Bioassay-directed fractionation of an extract of the marine species Spongia sp. led to the discovery of the new sesquiterpenoid derivative 17-O-isoprenyldictyoceratin-C (1), the known sesquiterpenoid derivative dictyoceratin-C (2), and the sesquiterpenoid quinone ilimaquinone (3), in addition to the nucleoside 2'-deoxyuridine. The structure of the new compound 1 was determined on the basis of spectroscopic methods and by conversion of dictyoceratin-C (2) to 1.

MeSH terms

  • Animals
  • DNA Polymerase beta / antagonists & inhibitors*
  • Deoxyuridine / chemistry
  • Deoxyuridine / isolation & purification
  • Deoxyuridine / pharmacology
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Lyases / antagonists & inhibitors*
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oceans and Seas
  • Porifera / chemistry*
  • Quinones / chemistry
  • Quinones / isolation & purification
  • Quinones / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology

Substances

  • 17-O-isoprenyldictyoceratin-C
  • Enzyme Inhibitors
  • Quinones
  • Sesquiterpenes
  • dictyoceratin-C
  • ilimaquinone
  • DNA Polymerase beta
  • Lyases
  • Deoxyuridine