Abstract
Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acne Vulgaris / immunology
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Acne Vulgaris / microbiology
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Amino Acid Motifs
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Amino Acid Sequence
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Antigens, Bacterial / chemistry
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Antigens, Bacterial / genetics
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Bacterial Proteins / chemistry
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Bacterial Proteins / genetics
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Bacterial Proteins / immunology
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Base Sequence
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Chromosomes, Bacterial / genetics
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Computational Biology
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Energy Metabolism
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Esterases / genetics
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Esterases / metabolism
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Genes, Bacterial
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Genome, Bacterial*
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Heat-Shock Proteins / chemistry
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Heat-Shock Proteins / genetics
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Humans
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Hydrolases / genetics
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Hydrolases / metabolism
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Lipase / genetics
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Lipase / metabolism
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Molecular Sequence Data
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Oxidative Phosphorylation
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Propionibacterium acnes / genetics*
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Propionibacterium acnes / immunology
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Propionibacterium acnes / physiology
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Sequence Analysis, DNA*
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Skin / microbiology*
Substances
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Antigens, Bacterial
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Bacterial Proteins
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Heat-Shock Proteins
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Hydrolases
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Esterases
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Lipase