Translesion DNA synthesis: little fingers teach tolerance

Oliver Fleck; Primo Schär

doi:10.1016/j.cub.2004.05.014

Translesion DNA synthesis: little fingers teach tolerance

Curr Biol. 2004 May 25;14(10):R389-91. doi: 10.1016/j.cub.2004.05.014.

Authors

Oliver Fleck¹, Primo Schär

Affiliation

¹ Institute of Molecular Cancer Research, University of Zürich, August-Forel Strasse 7, CH-8008 Zürich, Switzerland.

PMID: 15186765
DOI: 10.1016/j.cub.2004.05.014

Abstract

DNA synthesis on a damaged template requires tolerant DNA polymerases. Crystallographic analysis has captured a Y-family polymerase synthesizing across an abasic site, providing insight into the mechanisms of DNA damage tolerance and mutation.

Publication types

Review

MeSH terms

Base Sequence / genetics
DNA Damage*
DNA Replication / genetics
DNA Replication / physiology*
DNA-Directed DNA Polymerase / genetics
DNA-Directed DNA Polymerase / metabolism*
Models, Molecular*
Mutation / genetics
Protein Conformation

Substances

DNA-Directed DNA Polymerase