Eki2 is upregulated specifically in the testis during mouse sex determination

Gene Expr Patterns. 2004 Mar;4(2):135-40. doi: 10.1016/j.modgep.2003.09.010.

Abstract

We have identified a gene with gonad restricted expression throughout mouse development, which is orthologous to human EKI2 (ethanolamine kinase 2). Our studies showed that mouse Eki2 expression became upregulated in the male gonad during the period of sex determination. Expression was restricted to the Sertoli cells of the developing testis. Eki2 has sequence similarity to ethanolamine (73%) and choline kinases (54%).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Male
  • Mice
  • Molecular Sequence Data
  • Phosphotransferases (Alcohol Group Acceptor) / genetics*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Sequence Alignment
  • Testis / embryology
  • Testis / metabolism*
  • Up-Regulation

Substances

  • Phosphotransferases (Alcohol Group Acceptor)
  • ethanolamine kinase