A (CA)n repeat polymorphism for the human skeletal muscle alpha-actinin gene ACTN2 and its localization on the linkage map of chromosome 1

Genomics. 1992 Aug;13(4):1314-5. doi: 10.1016/0888-7543(92)90054-v.

Abstract

A CA dinucleotide repeat polymorphism has been identified for the skeletal muscle alpha-actinin gene ACTN2. The observed heterozygosity is 44% (predicted heterozygosity 50%, PIC 0.47). This polymorphic marker has been localized between D1S74 and D1S103 on the multipoint linkage map of chromosome 1 at a position 44.4 cM from the most distal marker D1S68 at 1 qter.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Actinin / genetics*
  • Base Sequence
  • Chromosome Mapping
  • Chromosomes, Human, Pair 1*
  • DNA
  • Genetic Linkage*
  • Heterozygote
  • Humans
  • Molecular Sequence Data
  • Muscles / metabolism*
  • Polymorphism, Genetic*
  • Repetitive Sequences, Nucleic Acid

Substances

  • Actinin
  • DNA